The recent lessons from the COVID-19 pandemic set the stage for a regional conversation on global health security. Convened by the University of Nebraska Medical Center and Jumuiya Ya Kaunti Za Pwani and planned for 28th to 30th January 2025 at the Prideinn Paradise Beach Resort & Convention Center, Mombasa Kenya, the EARGHSS 2025 will convene a diverse group of stakeholders and serve as a road map for countries across East Africa to work together to facilitate preparedness and response for pandemics and bioterrorism, bolster biosecurity, strengthen health systems, advance health equity, and accelerate innovative health technologies.