To answer the question, 'What if AI models in health care autocorrected to maintain peak clinical performance?', the Performance and Reliability Evaluation for Continuous Modifications and Useability of Artificial Intelligence (PRECISE-AI) program aims to develop capabilities that can automatically detect and mitigate AI model degradation. ARPA-H and PRECISE-AI aims to bring together machine learning experts, health information specialists, and clinicians to address five technical areas.